Systemic Lytic State (Last Updated - 3/30/2005)
-can be caused by too much:
A) plasminogen or
B) plasmin or
C) t-PA --> induces plasminogen activation to plasmin at ~100x the normal rate
-the alpha-2-anti-plasmin regulatory mechanism at max levels can only inhibit ~50% of max plasmin levels
-so high levels of either of the above will overwhelm the regulatory mechanism of alpha-2-anti-plasmin
-char. by uncontrolled clot lysis
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References:
Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.